Recent Publications by members of InHANSE
Matos L. L, Forster C. H. Q, Marta G. N, Castro Junior G, Ridge J. A, Hirata D, Miranda-Filho A, Hosny A., Sanabria A, Gregoire V, Patel S. G, Fagan J. J, D'Cruz, A. K, Licitra, L, Mehanna H, Hao, S-P, Psyrri A, Porceddu S, Galloway T. J, Golusinski W, Lee N. Y, Shiguemori E. H, Matieli J. E, Shiguemori A. P. A. C, Diamantino L. R., Schiaveto L. F, Leão L, Castro A. F, Carvalho A. L. & Kowalski L. P.
The hidden curve behind COVID-19 outbreak: the impact of delay in treatment initiation in cancer patients and how to mitigate the additional risk of dying-the head and neck cancer model
11 Mar 2021, In: Cancer Causes & Control.
Kong A, Mehanna H
WEE1 inhibitor: clinical development
Current Oncology Reports Accepted February 2021
Gorphe P, Brandbastien B, Dietz A, Duvvuri U, Ferris R, Golusinski W, Holsinger FC, Hosal S, Lawson G, Mehanna H, Paleri V, Shaw R, Succo G, Leemans CR, Simon C
Safety and feasibility of surgery for oropharyngeal cancers during the SARS-CoV-2-pandemic
Frontiers in Oncology Accepted February 2021
Whalley C, payne K, Domingo E, Blake A, Richman S, Brooks J, Batis N, Spruce R, S-cort Consortium, Mehanna H, Nankivell P, Beggs AD.
Ultra-Low DNA Input into Whole Genome Methylation Assays and Detection of Oncogenic Methylation and Copy Number Variants in Circulating Tumour DNA
Epigenomes 2021 5(1), 6; https://doi.org/10.3390/epigenomes5010006
Fouad S, Landini G, Robinson M, Song TH, Mehanna H
Human papilloma virus detection in oropharyngeal carcinomas with in situ hybridisation using hand crafted morphological features and deep central attention residual networks
Computerized Medical Imaging and Graphics. March 2021; Volume 88. doi.org/10.1016/j.compmedimag.2021.101853
Vreugdenhil M, Fong C, Sanghera P, Hartley A, Dunn J, Mehanna H
Hypofractionated chemoradiation for head and neck cancer: Data from the PET NECK trial.
Oral Oncology December 2020; https://doi.org/10.1016/j.oraloncology.2020.105112
Seebauer CT, Hackenberg B, Grosse J, Rennert J, Jung EM, ugele I, Michaelides I, Mehanna H, Hautmann MG, Bohr C, Kunzel J.
Routine restaging after primary non-surgical treatment of laryngeal squamous cell carcinoma – a review.
Strahlenther Onkol. doi.org/10.1007/s00066-020-01706-9
Kohler HF, Mehanna H, Shah JP, Sanabira A, Fagan J, Juriakose MA, Leemans R, et al
Comparison of different guidelines for oral cancer
European Archives of Oto-Rhino-Laryngology and Head & Neck. DOI 10.1007/s00405-020-06423-8
Gleneadie HJ, Baker AH, Batis N, Bryant J, Jiang Y, Clokie SJH, Mehanna H, Garcia P, Gendoo DMA, Roberts S, Molinolo AA, Gutkind JS, Scheven BA, Cooper PR, Khanim FL, Wiench M
The anti-tumour activity of DNA methylation inhibitor 5-aza-2′-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress
Cancer Lett. 2021 Jan 5;501:172-186. Doi: j.canlet.2020.12.029. PMID: 33359448
KreimerAR, Chaturvedi AK, Alemany L, Anantharaman D, Bray F, Carrington M, Doorbar J, D’Souza G, Fakhry C, Ferris R, Gillison M, Hayes DN, Hildesheim A, Huang SH, Kowalski LP, Lang Kuhs KA, Lewis J, Lowry D, Mehanna H, …. Brennan P
Summary from an international cancer seminar focused on human papillomavirus (HPV)-positive oropharynx cancer, convened by scientists at IARC and NCI
Oral Oncology. 2020 September. https://doi.org/10.1016/j.oraloncology.2020.104736
Mehanna H, Hardman JC, Shenson JA, Abou-Foul AK, Topf MC, AlFalasi M, et al.
Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus.
Lancet Oncology. 2020 June 11; DOI:https://doi.org/10.1016/S1470-2045(20)30334-X
INTEGRATE (UK ENT Trainee Research Network) Ellis M, Garas G, Hardman J, Khan M, Mehanna H, Smith ME, Tikka T, Ubayasiri K,Williams R
Post-Treatment Head and Neck Cancer Care: National Audit and Analysis of Current Practice in the United Kingdom in Clinical Otolaryngology
Clinical Otolaryngology 2020; http://dx.doi.org/10.1111/coa.13616
Fu T, Scheffler P, Forner D, Noel C, Huang S, Gilbert R, Goldstein D, O’SullivanB, Mehanna H, Waldron J, deAlmeida J.
A Cost Utility Analysis Comparing CT Surveillance, PET-CT Surveillance, and Planned Post-Radiation Neck Dissection for Advanced Nodal HPV-Positive Oropharyngeal Cancer
Cancer March 2021
Pansini, P. F., do Valle, I. B., Damasceno, T. C. D., de Abreu, P. M., Có, A. C. G., López, R. V. M., Lenzi, J., Rocha, R. M., Souza, E. D., Curado, M. P., Mehanna, H., Nankivell, P., de Podestá, J. R. V. & von Zeidler, S. V.
Differential Expression of Potential Biomarkers of Oral Squamous Cell Carcinoma Development
Head and Neck Pathology, 11 Apr 2021, (E-pub ahead of print)
Thariat J, Carsuzaa F, Lapeyre M, Gregoire V, MaingonP, Beddok A, Marcy PY, Salleron J, Coutte A, Racadot S, Pointreau Y, Graff P, Beadle B, Benezery K, Biau J, Calugaru V, Casteli J, Chua M, Rito A, Dore M, Ghadjar P, Huguet F, Jardel P, Johansen J, Kimple R, Krengli M, Laskar S, McDowell L, Nichols A, Tribius S, Valduvieco I, Hu C, Liem X, Moya-Plana A, D’Onofrio I, Parvathenen U, Takier V, Orlandi E, Psyrri A, Shenouda G, Sher D, Steuer C, Sun XS, Tao Y, Thomson D, Tsai MH, Vulquin N, Grophe P, Mehanna H, Yom S, Bourhis J.
Recommendations for postoperative radiotherapy in head & neck squamous cell carcinoma in the presence of flaps: a GORTEC internationally-reviewed HNCIG-endorsed consensus
Radiotherapy and Oncology; May 2021
Chaves ALF, Castro AF, Marta GN, Junior GC, Ferris RL, Giglio RE, Golusinski W, Gorphe P, Hosal S, Leemans CR, Magné N, Mehanna H, Mesía R, Netto E, Psyrri A, Sacco AG, Shah J, Simon C, Vermorken JB, Kowalski LP.
Oral Oncology June 2020.
Porceddu SV, Daniels C, Yom SS, Liu H, Waldron J, Gregoire V, Moore A, Veness M, Yao M, Johansen J, Mehanna H, Rischin D, Le QT.
Int J Radiat Oncol Biol Phys. 2020
Marinho de Abreu P, Bittencourt do Valle I, Damasceno TC, Gregorio Co AC, Pansini PF, Vasconcelos de Podesta JR, Duccini de Souza E, Rocha RM, Curado MP, Mehanna H, von Zeidler SV
Human Papillomavirus E6/E7 mRNA detection by in situ hybridization in oral cavity squamous cell carcinoma.
Archives of Oral Biology. 2020 May
Rohde M, Rosenberg T, Pareek M, Nankivell P, Sharma N, Mehanna H, Godballe C.
Eur Arch Otorhinolaryngol. 2020 Jun;
Malik A, Nair S, Singh A, Lamba K, Rane S, Bal M, Bhattacharjee A, Mehanna H, Chaturvedi P
Soft tissue deposit in neck dissection specimen carries a poor prognosis in oral cancer: A matched pair analysis.
Head Neck. 2020 Feb
Kong, A., Good, J. S., Kirkham, A., Savage, J., Mant, R., Llewellyn, L., Parish, J., Spruce, R., Forster, M., Schipani, S., Harrington, K., Sacco, J. J., Murray, P., Middleton, G., Yap, C. & Mehanna, H.
A phase I trial of WEE1 inhibition with chemotherapy and radiotherapy as adjuvant treatment, and a window of opportunity trial with cisplatin in patients with head and neck cancer: the WISTERIA trial protocol
BMJ open. 30 Jan 2020
Mehanna, H. & Sharma, N.
Prioritisation of research topics for head and neck cancer in Africa – report of the International Collaboration On Improving Cancer outcomes in low and middle income countries – ICOnIC Africa.
Oral Oncology. 2020
Wang Z, Li F, Rufo J, Chen C, Yang S, Li L, Zhang J, Cheng J, Kim Y, Wu M, Abemayor E, Tu M, Chia D, Spruce R, Batis N, Mehanna H, Wong DTW, Huang TJ.
Acoustofluidic Salivary Exosome Isolation: A Liquid Biopsy Compatible Approach for Human Papillomavirus-Associated Oropharyngeal Cancer Detection.
J Mol Diagn. 2020
Jones, D., Mistry, P., Dalby, M., Fulton-Lieuw, T., Kong, A., Dunn, J., Mehanna, H. & Gray, A. Concurrent cisplatin or cetuximab with radiotherapy for HPV-positive oropharyngeal cancer: medical resource use, costs, and quality-adjusted survival from the De-ESCALaTE HPV trial.
Jan 2020 European Journal of Cancer.
Lai SL, Tan, ML, Hollows RJ, Robinson M, Ibrahim M, Marielewska S, Parkinson EK, Ramanthan A, Zain RB, Mehanna H, Spruce R, Wei W, Chung I, Murray P, Yap LF, Paterson IC.
Collagen Induces a More Proliferative, Migratory and Chemoresistant Phenotype in Head and Neck Cancer via DDR1.
Cancers 2019
Bryant, J., Batis, N., Franke, A. C., Clancey, G., Hartley, M., Ryan, G., Brooks, J., Southam, A. D., Barnes, N., Parish, J., Roberts, S., Khanim, F., Spruce, R. & Mehanna, H.
Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma
OncoTarget 27 Aug 2019
Payne K, Brooks J, Spruce R, Batis N, Taylor G, Nankivell P, Mehanna H.
Circulating Tumour Cell Biomarkers in Head and Neck Cancer: Current Progress and Future Prospects.
Cancers (Basel). 2019
Cohen, E. E. W. & Mehanna, H.
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC)
J Immunother Cancer. 2019
Brooks JM, Menezes AN, Ibrahim M, Archer L, La Nl, Bagnall CJ, Zeidler SV, Valentine HR, Spruce RJ, Batis N, Bryant JL, Hartley M, Kaul N, Ryan GB, Bao R, Khattri A, Lee SL, Ogbureke KU, Middleton G, Tennant DA, Beggs AD, Deeks J, West CM, Cazier JB, Willcox BE, Seiwert TY and Mehanna H
Development and Validation of a Combined Hypoxia and Immune Prognostic Classifier for Head and Neck Cancer
Clin Cancer Res June 10 2019
Chatterjee S, Ghosh Laskar S, Mehanna H, Nutting CM, Mallick I.
Oropharyngeal Cancers in the East and the West - Implications of Aetiopathogenesis on Prognosis and Research.
Clin Oncol (R Coll Radiol). 2019
Roberts S, Evans D, Mehanna H, Parish JL,
Modelling human papillomavirus biology in oropharyngeal keratinocytes
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2019,
Farooq S, Khandavilli S, Dretzke J, Moore D, Nakivell P, Sharma N, de Almeida J, Winter S, Simon C, Paleri V, De M, Siddiq S. Holsinger C, Ferris R, Mehanna H.
Transoral tongue base mucosectomy for the identification of the primary site in the work-up of cancers of unknown origin: Systematic review and meta-analysis
Oral Oncology. 2019;
Singer S, Amdal CD, Hammerlid E, et al.
International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ‐HN43: Phase IV.
Head & Neck. 2019
Golusinski P, DiMaio P, Pehlivan B, Colley S, Nankivell P, Kong A, Hartley A, Mehanna H
Evidence for the approach to the diagnostic evaluation of squamous cell carcinoma occult primary tumors of the head and neck.
Oral Oncology. Jan 2019 88 (
Mehanna, H., Bryant, T. S., Babrah, J., Louie, K., Bryant, J., Spruce, R., Batis, N., Olaleye, O., Jones, J., Struijk, L., Molijn, A., Vorsters, A., Rosillon, D., Taylor, S. & D’Souza, G.,
Human Papillomavirus (HPV) vaccine effectiveness and potential herd immunity for reducing oncogenic oropharyngeal HPV16 prevalence in the UK: a cross-sectional study.
Clinical Infectious Diseases. 2019 Sep 2
Hollows R, Wei W, Cazier J‐B, et al.
Association between loss of Y chromosome and poor prognosis in male head and neck squamous cell carcinoma.
Head Neck. 2019 Apr
Mehanna H, Robinson M, Hartley A, Kong A, Foran B, Fulton-Lieuw T, Dalby M, Mistry P, Sen M, O’Toole L, Booz H, Dyker K, Moleron R, Whitaker S, Brennan S, Cook A, Griffin M, Aynsley E, Rolles M, DeWinton E, Chan A, Srinivasan S, Grumett, J, Leemans C, Buter J, Henderson J, Harrington K, McConkey C, Gray A, Dunn J, on behalf of the De-ESCALaTE HPV Trial Group.
Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial.
Lancet. 2019 Jan
Siu LL, Even C, Mesía R, Remenar E, Daste A, Delord JP, Krauss J, Saba NF, Nabell L, Ready NE, Braña I, Kotecki N, Zandberg DP, Gilbert J, Mehanna H, Bonomi M, Jarkowski A, Melillo G, Armstrong JM, Wildsmith S, Fayette J. Safety and Efficacy of Durvalumab With or Without Tremelimumab in Patients With PD-L1–Low/Negative Recurrent or Metastatic HNSCCThe Phase 2 CONDOR Randomized Clinical Trial. JAMA Oncol. Published online November 01, 2018.
Deschuymer, S., H. Mehanna and S. Nuyts.
Toxicity Reduction in the Treatment of HPV Positive Oropharyngeal Cancer: Emerging Combined Modality Approaches.
Frontiers in Oncology. 2018 8(439).
Borsetto D, Cheng J, Payne K, Nankivell P, Batis N, Rao K, Bhide S, Li F, Kim Y, Mehanna H, Wong D.
Surveillance of HPV-Positive Head and Neck Squamous Cell Carcinoma with Circulating and Salivary DNA Biomarkers
Critical Reviews in Oncogenesis. Vol 23, 2018.
Lin, D. J., McConkey, C. C., Nankivell, P., Dunn, J. & Mehanna, H.
The impact of institutional clinical trial recruitment versus hospital volume on survival outcomes of patients with head and neck cancer: An analysis of the PET-NECK trial outcomes, UKCRN portfolio, and Hospital Episode Statistics (HES) in England
1 Oct 2018 In : Oral Oncology
Simon C, Caballero C, Gregoire V, Thurnher D, Koivunen P, Ceruse P, Spriano G, Nicolai P, Licitra L, Machiels JP, Hamoir M, Andry G, Mehanna H, Hunter KD, Dietz A, René Leemans C.
Surgical quality assurance in head and neck cancer trials: an EORTC Head and Neck Cancer Group position paper based on the EORTC 1420 'Best of' and 24954 'larynx preservation' study
Eur J Cancer
Read M, Modasia B, Fletcher A, Thompson, R, Baker, K, Boelaert, K, Turnell, A, Smith, V, Mehanna, H & McCabe, C.
PTTG and PBF functionally interact with P53 and predict overall survival in head and neck cancer
Cancer Research
Abdelrahim, A., Balmer, C., Jones, J., Mehanna, H. & Dunn, J.
Considerations for a head and neck smoking cessation support programme; A qualitative study of the challenges in quitting smoking after treatment for head and neck cancer
European Journal of Oncology Nursing.
Paleri V, Sawant R, Mehanna H, Ainsworth H, and Stocken D
Laryngeal Dysplasia and narrow band imaging: secondary analysis of published data supports the role in patient follow up
Clinical Otolaryngology
Read M, Modasia B, Fletcher A, Thompson, R, Baker, K, Boelaert, K, Turnell, A, Smith, V, Mehanna, H & McCabe, C.
PO-124 PTTG and PBF functionally interact with P53 and predict overall survival in head and neck cancer
ESMO Open 2018;3:
Best, J, Fong, C, Benghiat, H, Mehanna, H, Glaholm, J, & Hartley J.
Revised Modelling of the Addition of Synchronous Chemotherapy to Radiotherapy in Squamous Cell Carcinoma of the Head and Neck—A Low α/β?
Medicines 2018, 5(2), 54
Robinson, M., Ward, L., Mehanna, H., Paleri, V. & Winter, S. C.
Provision of physiotherapy rehabilitation following neck dissection in the UK
The Journal of laryngology and otology. 2018;1–4.
Meade, S., Gaunt, P., Hartley, A., Robinson, M., Cashmore, J., Wagstaff, L., Babrah, J., Bowden, S. J., Mehanna, H. & Sanghera, P.
Feasibility of Dose-escalated Hypofractionated Chemoradiation in Human Papilloma Virus-negative or Smoking-associated Oropharyngeal Cancer
Clinical Oncology. June 2018 Volume 30, Issue 6, Pages 366–374
Grønhøj, C. , Jensen, D. H. , Dehlendorff, C. , Marklund, L. , Wagner, S. , Mehanna, H. , Munck-Wikland, E. , Ramqvist, T. , Näsman, A. , Wittekindt, C. , Würdemann, N. , Sharma, S. J. , Gattenlöhner, S. , Kiss, K. , Andersen, E. , Spruce, R. , Batis, N. , Robinson, M. , Harrington, K. , Winter, S. & 5 others
Development and external validation of nomograms in oropharyngeal cancer patients with known HPV-DNA status: a European Multicentre Study (OroGrams)
British Journal of Cancer. 24 May 118, pages1672–1681 (2018)
Payne K, Spruce R, Beggs A, Sharma N, Kong A, Martin T, Parmar S, Praveen P, Nankivell P, Mehanna H.
Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma.
Basic Science Review. March 2018.
Fussey, J. M., Bryant, J. L., Batis, N., Spruce, R. J., Hartley, A., Good, J. S., McCabe, C. J., Boelaert, K., Sharma, N. & Mehanna, H
The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review.
Frontiers in oncology. 30 Apr 2018 , 132
Abdelrahim, A., Balmer, C., Jones, J., Mehanna, H. & Dunn, J.
Considerations for a head and neck smoking cessation support programme; A qualitative study of the challenges in quitting smoking after treatment for head and neck cancer
European Journal of Oncology Nursing. Volume 35, August 2018, Pages 54-611
Robinson, M., Ward, L., Mehanna, H., Paleri, V. & Winter, S. C.
Provision of physiotherapy rehabilitation following neck dissection in the UK
The Journal of laryngology and otology. 2018;1–4.
Grønhøj, C. , Jensen, D. H. , Dehlendorff, C. , Marklund, L. , Wagner, S. , Mehanna, H. , Munck-Wikland, E. , Ramqvist, T. , Näsman, A. , Wittekindt, C. , Würdemann, N. , Sharma, S. J. , Gattenlöhner, S. , Kiss, K. , Andersen, E. , Spruce, R. , Batis, N. , Robinson, M. , Harrington, K. , Winter, S. & 5 others
Development and external validation of nomograms in oropharyngeal cancer patients with known HPV-DNA status: a European Multicentre Study (OroGrams)
British Journal of Cancer. 24 May 118, pages1672–1681 (2018)
Meade, S., Gaunt, P., Hartley, A., Robinson, M., Cashmore, J., Wagstaff, L., Babrah, J., Bowden, S. J., Mehanna, H. & Sanghera, P.
Feasibility of Dose-escalated Hypofractionated Chemoradiation in Human Papilloma Virus-negative or Smoking-associated Oropharyngeal Cancer
Clinical Oncology. June 2018 Volume 30, Issue 6, Pages 366–374
Fussey, J. M., Bryant, J. L., Batis, N., Spruce, R. J., Hartley, A., Good, J. S., McCabe, C. J., Boelaert, K., Sharma, N. & Mehanna, H
The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review.
Frontiers in oncology. 30 Apr 2018 , 132
Abdelrahim, A., Balmer, C., Jones, J., Mehanna, H. & Dunn, J.
Considerations for a head and neck smoking cessation support programme; A qualitative study of the challenges in quitting smoking after treatment for head and neck cancer
European Journal of Oncology Nursing. Volume 35, August 2018, Pages 54-611
Robinson, M., Ward, L., Mehanna, H., Paleri, V. & Winter, S. C.
Provision of physiotherapy rehabilitation following neck dissection in the UK
The Journal of laryngology and otology. 2018;1–4.
Grønhøj, C. , Jensen, D. H. , Dehlendorff, C. , Marklund, L. , Wagner, S. , Mehanna, H. , Munck-Wikland, E. , Ramqvist, T. , Näsman, A. , Wittekindt, C. , Würdemann, N. , Sharma, S. J. , Gattenlöhner, S. , Kiss, K. , Andersen, E. , Spruce, R. , Batis, N. , Robinson, M. , Harrington, K. , Winter, S. & 5 others
Development and external validation of nomograms in oropharyngeal cancer patients with known HPV-DNA status: a European Multicentre Study (OroGrams)
British Journal of Cancer. 24 May 118, pages1672–1681 (2018)
Meade, S., Gaunt, P., Hartley, A., Robinson, M., Cashmore, J., Wagstaff, L., Babrah, J., Bowden, S. J., Mehanna, H. & Sanghera, P.
Feasibility of Dose-escalated Hypofractionated Chemoradiation in Human Papilloma Virus-negative or Smoking-associated Oropharyngeal Cancer
Clinical Oncology. June 2018 Volume 30, Issue 6, Pages 366–374
Fussey, J. M., Bryant, J. L., Batis, N., Spruce, R. J., Hartley, A., Good, J. S., McCabe, C. J., Boelaert, K., Sharma, N. & Mehanna, H
The Clinical Utility of Cell-Free DNA Measurement in Differentiated Thyroid Cancer: A Systematic Review.
Frontiers in oncology. 30 Apr 2018 , 132
Payne K, Spruce R, Beggs A, Sharma N, Kong A, Martin T, Parmar S, Praveen P, Nankivell P, Mehanna H.
Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma.
Basic Science Review. March 2018.
Cost-effectiveness analysis of PET-CT-guided management for locally advanced head and neck cancer
Smith, A. F., Hall, P. S., Hulme, C. T., McCabe, C. & Mehanna, H
European Journal of Cancer. November 2017, Volume 85, P. 6-14
Formation of an international intergroup to coordinate clinical trials in head and neck cancers: HNCIG
Le, Q. T., Welch, J. J., Vermorken, J. B., Rischin, D., Mehanna, H. & investigators, H. N. C. I. G. Aug 2017
Oral Oncology. 71, p. 180-18
A Q methodology study to investigate the experiences of head and neck cancer patients from diagnosis to one year
Reid, K. J., Mehanna, H. & Swift, A. 4 May 2017
European journal of cancer care
Model-based Correction of Segmentation Errors in Digitised Histological Images
Randell, D., Galton, A., Fouad, S., Mehanna, H. & Landini, G. 19 Apr 2017
Medical image understanding and analysis - MIUA 2017.
PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography-computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer
Mehanna, H., McConkey, C. C., Rahman, J. K., Wong, W-L., Smith, A. F., Nutting, C., Hartley, A. G., Hall, P., Hulme, C., Patel, D. K., Zeidler, S. V. V., Robinson, M., Sanghera, B., Fresco, L. & Dunn, J. A. Apr 2017
Health Technology Assessment. 21, 17, p. 1-122 122 p.
Unsupervised Superpixel-based Segmentation of Histopathological Images with Consensus Clustering
Fouad, S., Randell, D., Galton, A., Mehanna, H. & Landini, G. 2017 Medical Image Understanding and Analysis: 21st Annual Conference, MIUA 2017, Edinburgh, UK, July 11-13, 2017, Proceedings. Springer, (Communications in Computer and Information Science; vol. 723)
Existing evidence on noise induced hearing loss and tinnitus in the military and other occupational groups.
Evidence Synthesis Team, Institute of Applied Health Research, University of Birmingham, January 2017 ISBN No: 9780704429420
Pro-invasive effect of proto-oncogene PBF is modulated by an interaction with cortactin.
Rachel J Watkins, Waraporn Imruetaicharoenchoke, Martin L Read, Neil Sharma, Vikki L Poole, Erica Gentillin, Sukhchain Bansal, Emy Bosseboeuf, Rachel Fletcher, Hannah R Nieto, Ujjal Mallick, Allan Hackshaw, Hisham Mehanna, Kristien Boelaert, Vicki E Smith, Christopher J McCabe.
The Journal of clinical endocrinology and metabolism. 2016, 2016, p. jc20161932
Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: A systematic review and meta-analysis.
Sharan Chakkyath Jayaram, Sayed Jameel Muzaffar, Ikhlaaq Ahmed, Jagtar Dhanda, Vinidh Paleri, Hisham Mehanna.
Head & Neck 2016
HPV-related oropharyngeal cancer in the United Kingdom: an evolution in understanding of disease etiology.
Andrew G Schache, Ned G Powell, Kate S Cuschieri, Max Robinson, Sam Leary, Hisham Mehanna, Davy Rapozo, Anna Long, Heather Cubie, Elizabeth Junor, Hannah Monaghan, Kevin J Harrington, Christopher M Nutting, Ulrike Schick, Andy S Lau, Nav Upile, Jon Sheard, Kath Brougham, Catharine M L West, Ken Oguejiofor & 12 others.
Cancer research 2016
ENT Trainee Research Collaborative – West Midlands. National prospective cohort study of peritonsillar abscess management and outcomes: the Multicentre Audit of Quinsies study.
J Laryngol Otol. 2016 Jun 10;1–9. DOI: 10.1017/S0022215116008173 PMID: 27282632
PETCT – guided surveillance versus planned neck dissection in advanced nodal disease of head and neck cancer treated by chemoradiotherapy
Mehanna H, Wong WL, McConkey C, Rahman JK, Robinson M, Hartley AG, Nutting C, Powell N, Al-Booz H, Robinson M, Junor E, Hulme C, Smith AF, Hall P, Dunn J.
N Engl J Med. 2016 Apr 14;374(15):1444-54. doi: 10.1056/NEJMoa1514493. Epub 2016 Mar 23. PMID: 27007578
Management of advanced nodal disease in patients treated with primary chemoradiotherapy.
Mehanna H, Wong WL, Dunn J.
Curr Opin Oncol. 2016 May;28(3):201-4. doi: 10.1097/CCO.0000000000000283.
HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients
Xavier Castellsague; Laia Alemany; Miquel Quer; Gordana Halec; Beatriz Quiros; Sara Tous; Omar Clavero; Llucia Alos; Thorsten Biegner; Tomasz Szafarowski; Maria Alejo; Dana Holzinger; Enrique Cadena; Edith Claros; Gillian Hall; Jan Laco; Mario Poljak; Maria Benevolo; Elena Kasamatsu; Hisham Mehanna; Cathy Ndiaye; Nuria Guimera; Belen Lloveras; Xavier Leon; Juan C. Ruiz-Cabezas; Isabel Alvarado-Cabrero; Chang-Suk Kang; Jin-Kyoung Oh; Marcial Garcia-Rojo; Ermina Iljazovic; Oluseyi F. Ajayi; Flora Duarte; Ashrafun Nessa; Leopoldo Tinoco; Marco A. Duran-Padilla; Edyta C. Pirog; Halina Viarheichyk; Hesler Morales; Valerie Costes; Ana Felix; Maria Julieta V. Germar; Marisa Mena; Arzu Ruacan; Asha Jain; Ravi Mehrotra; Marc T. Goodman; Luis Estuardo Lombardi; Annabelle Ferrera; Sani Malami; Estela I. Albanesi; Pablo Dabed; Carla Molina; Ruben Lopez-Revilla; Vaclav Mandys; Manuel E. Gonzalez; Julio Velasco; Ignacio G. Bravo; Wim Quint; Michael Pawlita; Nubia Munoz; Silvia de Sanjose; F. Xavier Bosch.
JNCI Journal of the National Cancer Institute 2016 108 (6): djv403 doi: 10.1093/jnci/djv403
Geographic variation in human papillomavirus oropharyngeal cancer: Data from 4 multi-national randomised trials.
Mehanna H, Franklin N, Compton N, Robinson M, Powell N, Biswas-Baldwin N, Paleri V, Hartley A, Fresco L, Al-Booz H, Junor E, El-Hariry I, Roberts S, Harrington K, Ang K, Dunn J, Woodman C.
Head and Neck, in print 2015
Postoperative Adjuvant Lapatinib and Concurrent Chemoradiotherapy Followed by Maintenance Lapatinib Monotherapy in High-Risk Patients With Resected Squamous Cell Carcinoma of the Head and Neck: A Phase III, Randomized, Double-Blind, Placebo-Controlled Study
Harrington K, Temam S, Mehanna H, D'Cruz A, Jain M, D'Onofrio I, Manikhas G, Horvath Z, Sun Y, Dietzsch S, Dubinsky P, Holeckova P, El-Hariry I, Franklin N, Biswas-Baldwin N, Legenne P, Wissel P, Netherway T, Farrell J, Ellis C, Wang-Silvanto J, Amonkar M, Ahmed N, Santillana S, Bourhis J.
J Clin Oncol. 2015 Nov 2. pii: JCO.2015.61.4370. [Epub ahead of print]
Interventions in randomised controlled trials in surgery: issues to consider during trial design.
Blencowe NS, Brown JM, Cook JA, Metcalfe C, Morton DG, Nicholl J, Sharples LD, Treweek S, Blazeby JM; Members of the MRC Hub for Trials Methodology Research Network Workshop.
Trials. 2015 Sep 4;16:392. doi: 10.1186/s13063-015-0918-4.
The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.
Sahasrabudhe R1, Estrada A1, Lott P1, Martin L1, Polanco Echeverry G2, Velez A1, Neta G1, Takahasi M2, Saenko V1, Mitsutake N; JTCMS Consortium, Jaeguer E1, Duque CS1, Rios A1, Bohorquez M1, Prieto R1, Criollo A1, Echeverry M1, Tomlinson I1; CORGI Consortium; TCUKIN Consortiums, Carmona LG2.
Endocr Relat Cancer. 2015 Oct;22(5):841-9. doi: 10.1530/ERC-15-0081. Epub 2015 Aug 19.
External beam radiotherapy in differentiated thyroid carcinoma: A systematic review.
Fussey JM, Crunkhorn R, Tedla M, Weickert MO, Mehanna H
Head Neck. 2015 Sep 3. doi: 10.1002/hed.24218. [Epub ahead of print]
IGF-1R expression is associated with HPV-negative status and adverse survival in head and neck squamous cell cancer.
Dale OT, Aleksic T, Shah KA, Han C, Mehanna H, Rapozo DC, Sheard JD, Goodyear P, Upile NS, Robinson M, Jones TM, Winter S, Macaulay VM.
Carcinogenesis. 2015 Jun;36(6):648-55. doi: 10.1093/carcin/bgv053. Epub 2015 Apr 20
Trends in head and neck cancers in England from 1995 to 2011 and projections up to 2025.
Louie KS, Mehanna H, Sasieni P
Oral Oncol. 2015 Jan 22. pii: S1368-8375(15)00003-2. doi: 10.1016/j.oraloncology.2015.01.002. [Epub ahead of print]
Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000.
Ness AR, Waylen A, Hurley K, Jeffreys M, Penfold C, Pring M, Leary S, Allmark C, Toms S, Ring S, Peters TJ, Hollingworth W, Worthington H, Nutting C, Fisher S, Rogers SN, Thomas SJ; Head and Neck 5000 Study Team
BMC Cancer. 2014 Dec 17;14:973. doi: 10.1186/1471-2407-14-973.
Resection of subsequent pulmonary metastases from treated head and neck squamous cell carcinoma; systematic review and meta-analysis.
Young ER, Diakos E, Khalid-Raja M, Mehanna H.
Clin Otolaryngol. 2014 Oct 30. doi: 10.1111/coa.12348. [Epub ahead of print]
PMID: 25358605 [PubMed - as supplied by publisher]
Differences in the Recurrence and Mortality Outcomes Rates of Incidental and Nonincidental Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-Analysis of 21 329 Person-Years of Follow-Up.
Mehanna H, Al-Maqbili T, Carter B, Martin E, Campain N, Watkinson J, McCabe C, Boelaert K, Franklyn JA.
J Clin Endocrinol Metab. 2014 May 14:jc20132118. [Epub ahead of print]
Investigation of p16(INK4a) as a prognostic biomarker in oral epithelial dysplasia.
Nankivell P, Williams H, Webster K, Pearson D, High A, MacLennan K, Senguven B, McConkey C, Rabbitts P, Mehanna H.
J Oral Pathol Med. 2014 Apr;43(4):245-9. doi: 10.1111/jop.12128. Epub 2013 Dec 26.
PMID:
24372672
[PubMed - in process]
Revised radiobiological modelling of the contribution of synchronous chemotherapy to the rate of grades 3-4 mucositis in head and neck cancer.
Meade S, McConkey C, Sanghera P, Mehanna H, Hartley A.
J Med Imaging Radiat Oncol. 2013 Dec;57(6):733-8; quiz 739-40. doi: 10.1111/1754-9485.12096. Epub 2013 Jul 9.
Tetraspanins CD9 and CD151, epidermal growth factor receptor and cyclooxygenase-2 expression predict malignant progression in oral epithelial dysplasia.
Nankivell P, Williams H, McConkey C, Webster K, High A, MacLennan K, Senguven B, Rabbitts P, Mehanna H.
Br J Cancer. 2013 Nov 26;109(11):2864-74. doi: 10.1038/bjc.2013.600. Epub 2013 Nov 7.
LIHNCS - Lugol's iodine in head and neck cancer surgery: a multicentre, randomised controlled trial assessing the effectiveness of Lugol's iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in situ at mucosal resection margins of oral and oropharyngeal squamous cell carcinoma: study protocol for a randomised controlled trial.
McCaul JA, Cymerman JA, Hislop S, McConkey C, McMahon J, Mehanna H, Shaw R, Sutton DN, Dunn J.
Trials. 2013 Sep 24;14:310. doi: 10.1186/1745-6215-14-310.
Simplified bone-anchored hearing aid insertion using a linear incision without soft tissue reduction.
Husseman J, Szudek J, Monksfield P, Power D, O’Leary S, Briggs R
J Laryngol Otology, 2013 Jul;127 Suppl 2:S33-8
Surgical trials in head & neck cancer - Are you serious?
Shaw R, Mehanna H.
Oral Oncol. 2013 Jun 28. doi:pii: S1368-8375(13)00609-X. 10.1016/j.oraloncology.2013.06.004. [Epub ahead of print]
Prolonged treatment with vitamin D in postmenopausal women with primary hyperparathyroidism.
Rao RR, Randeva HS, Sankaranarayanan S, Narashima M, Möhlig M, Mehanna H, Weickert MO.
Endocr Connect. 2012 Jun 8;1(1):13-21. doi: 10.1530/EC-12-0008. Print 2012 Jul 1.
Oncologic outcomes of transoral laser microsurgery for radiorecurrent laryngeal carcinoma: A systematic review and meta-analysis of English-language literature.
Ramakrishnan Y, Drinnan M, Kwong FN, Grant DG, Mehanna H, Jones T, Paleri V.
Head Neck. 2013 Jun 14. doi: 10.1002/hed.23291. [Epub ahead of print]
Barriers to recruitment for surgical trials in head and neck oncology: a survey of trial investigators.
Kaur G, Hutchison I, Mehanna H, Williamson P, Shaw R, Tudur Smith C.
BMJ Open. 2013 Apr 11;3(4). doi:pii: e002625. 10.1136/bmjopen-2013-002625. Print 2013.
Relations between cochlear histopathology and hearing loss in experimental cochlear implantation
SJ O'Leary, P Monksfield, G Kel, T Connolly, MA Souter, A Chang, P Marovic, JS O’Leary, R Richardson, H Eastwood
Hearing Research, 2013 Apr 298: 27-35
Randomised Phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: rationale for future randomised trials in human papilloma virus-negative disease.
Harrington K, Berrier A, Robinson M, Remenar E, Housset M, de Mendoza FH, Fayette J, Mehanna H, El-Hariry I, Compton N, Franklin N, Biswas-Baldwin N, Lau M, Legenne P, Kumar R.
Eur J Cancer. 2013 May;49(7):1609-18. doi: 10.1016/j.ejca.2012.11.023. Epub 2012 Dec 19.
The binary oral dysplasia grading system: validity testing and suggested improvement.
Nankivell P, Williams H, Matthews P, Suortamo S, Snead D, McConkey C, Mehanna H.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jan;115(1):87-94. doi: 10.1016/j.oooo.2012.10.015.
Malignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid.
Al Maqbali T, Tedla M, Weickert MO, Mehanna H.
PLoS One. 2012;7(11):e49078. doi: 10.1371/journal.pone.0049078. Epub 2012 Nov 19.
Salivary gland swellings.
Mehanna H, McQueen A, Robinson M, Paleri V.
BMJ. 2012 Oct 23;345:e6794. doi: 10.1136/bmj.e6794. Review. No abstract available.
Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis.
Rainsbury JW, Ahmed W, Williams HK, Roberts S, Paleri V, Mehanna H.
Head Neck. 2013 Jul;35(7):1048-55. doi: 10.1002/hed.22950. Epub 2012 Sep 20.
The new Nucleus 5 model cochlear implant: a new surgical technique and early clinical results.
Monksfield P, Husseman J, Cowan RSC, O’Leary SJ, Briggs RJS
Cochlear Implants International, 2012 Aug;13(3): 142-7
Validation of tissue microarrays in oral epithelial dysplasia using a novel virtual-array technique.
Nankivell PC, Williams H, Bartlett JM, Mehanna H.
J Clin Pathol. 2012 Dec;65(12):1084-7. doi: 10.1136/jclinpath-2012-200974. Epub 2012 Aug 22.
Feasibility of recruitment to an oral dysplasia trial in the United Kingdom.
Nankivell P, Dunn J, Langman M, Mehanna H.
Head Neck Oncol. 2012 Jun 25;4:40.
PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.
Smith VE, Read ML, Turnell AS, Sharma N, Lewy GD, Fong JC, Seed RI, Kwan P, Ryan G, Mehanna H, Chan SY, Darras VM, Boelaert K, Franklyn JA, McCabe CJ.
Endocrinology. 2012 Jul;153(7):3526-36. doi: 10.1210/en.2011-2030. Epub 2012 Apr 25.
Oropharyngeal cancer - is it time to change management according to human papilloma virus status?
Mehanna H, Olaleye O, Licitra L.
Curr Opin Otolaryngol Head Neck Surg. 2012 Apr;20(2):120-4. doi: 10.1097/MOO.0b013e3283509735.
Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24.
Jones AM, Howarth KM, Martin L, Gorman M, Mihai R, Moss L, Auton A, Lemon C, Mehanna H, Mohan H, Clarke SE, Wadsley J, Macias E, Coatesworth A, Beasley M, Roques T, Martin C, Ryan P, Gerrard G, Power D, Bremmer C; TCUKIN Consortium, Tomlinson I, Carvajal-Carmona LG.
J Med Genet. 2012 Mar;49(3):158-63. doi: 10.1136/jmedgenet-2011-100586. Epub 2012 Jan 25.
Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer--systematic review and meta-analysis of trends by time and region.
Mehanna H, Beech T, Nicholson T, El-Hariry I, McConkey C, Paleri V, Roberts S.
Head Neck. 2013 May;35(5):747-55. doi: 10.1002/hed.22015. Epub 2012 Jan 20.
Variation in volume definition between UK head and neck oncologists treating oropharyngeal carcinoma.
Pettit L, Hartley A, Bowden SJ, Mehanna H, Glaholm J, Cashmore J, Sanghera P.
Clin Oncol (R Coll Radiol). 2011 Nov;23(9):654-5. doi: 10.1016/j.clon.2011.07.006. Epub 2011 Aug 4. No abstract available.
Dexamethasone reduces pain, vomiting and overall complications following tonsillectomy in adults: a systematic review and meta-analysis of randomised controlled trials.
Diakos EA, Gallos ID, El-Shunnar S, Clarke M, Kazi R, Mehanna H.
Clin Otolaryngol. 2011 Dec;36(6):531-42. doi: 10.1111/j.1749-4486.2011.02373.x. Review.
Open conservation partial laryngectomy for laryngeal cancer: a systematic review of English langCost Effectiveness (Utility) Analysis of Bone Anchored Hearing Aids.
Monksfield P, Jowett S, Reid AP and Proops DW
Otology Neurotology, 2011 Oct;32(8):1192-7
Biofilm formation on bone-anchored hearing aids
Monksfield P, Chapple ILC, Matthews JB, Grant MM, Addison O, Reid AP, Proops DW, Sammons RL
J Laryngol Otology, 2011 Nov;125(11):1125-30uage literature.
Open conservation partial laryngectomy for laryngeal cancer: a systematic review of English language literature.
Thomas L, Drinnan M, Natesh B, Mehanna H, Jones T, Paleri V.
Cancer Treat Rev. 2012 May;38(3):203-11. doi: 10.1016/j.ctrv.2011.05.010. Epub 2011 Jul 20. Review.
Biomarkers in laryngeal dysplasia: a systematic review.
Nankivell P, Weller M, McConkey C, Paleri V, Mehanna H.
Head Neck. 2011 Aug;33(8):1170-6. doi: 10.1002/hed.21592. Epub 2010 Nov 17. Review.
Re-feeding syndrome in head and neck--prevention and management.
Ahmed S, Travis J, Mehanna H.
Oral Oncol. 2011 Sep;47(9):792-6. doi: 10.1016/j.oraloncology.2010.06.009. Epub 2011 Jul 5. Review.
Head and neck cancer-part 1: epidemiology, presentation, and preservation.
Mehanna H, Paleri V, West CM, Nutting C.
Clin Otolaryngol. 2011 Feb;36(1):65-8. doi: 10.1111/j.1749-4486.2010.02231.x. Review. No abstract available.
Oncologic outcomes of open conservation laryngectomy for radiorecurrent laryngeal carcinoma: a systematic review and meta-analysis of English-language literature.
Paleri V, Thomas L, Basavaiah N, Drinnan M, Mehanna H, Jones T.
Cancer. 2011 Jun 15;117(12):2668-76. doi: 10.1002/cncr.25831. Epub 2011 Feb 1.
Review.Oral dysplasia: biomarkers, treatment, and follow-up.
Nankivell P, Mehanna H.
Curr Oncol Rep. 2011 Apr;13(2):145-52. doi: 10.1007/s11912-010-0150-z.
The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis.
Weller MD, Nankivell PC, McConkey C, Paleri V, Mehanna HM.
Clin Otolaryngol. 2010 Oct;35(5):364-72. doi: 10.1111/j.1749-4486.2010.02181.x. Review.
Who should be offered sperm banking for fertility preservation? A survey of UK oncologists and haematologists.
Gilbert E, Adams A, Mehanna H, Harrison B, Hartshorne GM.
Ann Oncol. 2011 May;22(5):1209-14. doi: 10.1093/annonc/mdq579. Epub 2010 Oct 27.
Head and neck cancer--Part 2: Treatment and prognostic factors.
Mehanna H, West CM, Nutting C, Paleri V.
BMJ. 2010 Sep 28;341:c4690. doi: 10.1136/bmj.c4690. Review.
Hypofractionated accelerated radiotherapy with concurrent carboplatin for locally advanced squamous cell carcinoma of the head and neck.
Chan AK, Sanghera P, Choo BA, McConkey C, Mehanna H, Parmar S, Pracy P, Glaholm J, Hartley A.
Clin Oncol (R Coll Radiol). 2011 Feb;23(1):34-9. doi: 10.1016/j.clon.2010.07.015. Epub 2010 Sep 21.
Head and neck cancer--Part 1: Epidemiology, presentation, and prevention.
Mehanna H, Paleri V, West CM, Nutting C.
BMJ. 2010 Sep 20;341:c4684. doi: 10.1136/bmj.c4684. Review.
Correlation of currently used radiobiological parameters with local control and acute and late mucosal toxicity in randomised studies of altered fractionation for locally advanced head and neck cancer.
Hartley A, Sanghera P, Kazi W, Mehanna H, McConkey C, Glaholm J, Fowler J.
Clin Oncol (R Coll Radiol). 2011 Feb;23(1):29-33. doi: 10.1016/j.clon.2010.08.007. Epub 2010 Sep 9.
