InHANSE Institute of Head and Neck Studies and Education Contact Us

Recent Publications by members of InHANSE

Payne K, Spruce R, Beggs A, Sharma N, Kong A, Martin T, Parmar S, Praveen P, Nankivell P, Mehanna H.

Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma.

Basic Science Review.  March 2018.   

Cost-effectiveness analysis of PET-CT-guided management for locally advanced head and neck cancer

Smith, A. F., Hall, P. S., Hulme, C. T., McCabe, C. & Mehanna, H

European Journal of Cancer.  November 2017, Volume 85, P. 6-14

Formation of an international intergroup to coordinate clinical trials in head and neck cancers: HNCIG

Le, Q. T., Welch, J. J., Vermorken, J. B., Rischin, D., Mehanna, H. & investigators, H. N. C. I. G. Aug 2017 

Oral Oncology. 71, p. 180-18

A Q methodology study to investigate the experiences of head and neck cancer patients from diagnosis to one year

Reid, K. J., Mehanna, H. & Swift, A. 4 May 2017

 European journal of cancer care

Model-based Correction of Segmentation Errors in Digitised Histological Images

Randell, D., Galton, A., Fouad, S., Mehanna, H. & Landini, G. 19 Apr 2017 

Medical image understanding and analysis - MIUA 2017.

PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography-computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer

Mehanna, H., McConkey, C. C., Rahman, J. K., Wong, W-L., Smith, A. F., Nutting, C., Hartley, A. G., Hall, P., Hulme, C., Patel, D. K., Zeidler, S. V. V., Robinson, M., Sanghera, B., Fresco, L. & Dunn, J. A. Apr 2017 

Health Technology Assessment. 21, 17, p. 1-122 122 p.

Unsupervised Superpixel-based Segmentation of Histopathological Images with Consensus Clustering

Fouad, S., Randell, D., Galton, A., Mehanna, H. & Landini, G. 2017 Medical Image Understanding and Analysis: 21st Annual Conference, MIUA 2017, Edinburgh, UK, July 11-13, 2017, Proceedings. Springer, (Communications in Computer and Information Science; vol. 723)

Existing evidence on noise induced hearing loss and tinnitus in the military and other occupational groups.

Evidence Synthesis Team, Institute of Applied Health Research, University of Birmingham, January 2017  ISBN No: 9780704429420

Pro-invasive effect of proto-oncogene PBF is modulated by an interaction with cortactin.

Rachel J Watkins, Waraporn Imruetaicharoenchoke, Martin L Read, Neil Sharma, Vikki L Poole, Erica Gentillin, Sukhchain Bansal, Emy Bosseboeuf, Rachel Fletcher, Hannah R Nieto, Ujjal Mallick, Allan Hackshaw, Hisham Mehanna, Kristien Boelaert, Vicki E Smith, Christopher J McCabe. 

The Journal of clinical endocrinology and metabolism.  2016, 2016, p. jc20161932

Efficacy, outcomes, and complication rates of different surgical and nonsurgical treatment modalities for recurrent/residual oropharyngeal carcinoma: A systematic review and meta-analysis.

Sharan Chakkyath Jayaram, Sayed Jameel Muzaffar, Ikhlaaq Ahmed, Jagtar Dhanda, Vinidh Paleri, Hisham Mehanna

Head & Neck 2016



HPV-related oropharyngeal cancer in the United Kingdom: an evolution in understanding of disease etiology. 

Andrew G Schache, Ned G Powell, Kate S Cuschieri, Max Robinson, Sam Leary, Hisham Mehanna, Davy Rapozo, Anna Long, Heather Cubie, Elizabeth Junor, Hannah Monaghan, Kevin J Harrington, Christopher M Nutting, Ulrike Schick, Andy S Lau, Nav Upile, Jon Sheard, Kath Brougham, Catharine M L West, Ken Oguejiofor & 12 others.

Cancer research 2016


ENT Trainee Research Collaborative – West Midlands. National prospective cohort study of peritonsillar abscess management and outcomes: the Multicentre Audit of Quinsies study.

J Laryngol Otol. 2016 Jun 10;1–9. DOI: 10.1017/S0022215116008173  PMID: 27282632

PETCT – guided surveillance versus planned neck dissection in advanced nodal disease of  head and neck cancer treated by chemoradiotherapy

Mehanna H, Wong WL, McConkey C, Rahman JK, Robinson M, Hartley AG, Nutting C, Powell N, Al-Booz H, Robinson M, Junor E, Hulme C, Smith AF, Hall P, Dunn J.

N Engl J Med. 2016 Apr 14;374(15):1444-54. doi: 10.1056/NEJMoa1514493. Epub 2016 Mar 23. PMID: 27007578

Management of advanced nodal disease in patients treated with primary chemoradiotherapy.

Mehanna H, Wong WL, Dunn J. 

Curr Opin Oncol. 2016 May;28(3):201-4. doi: 10.1097/CCO.0000000000000283.


HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients

 Xavier Castellsague; Laia Alemany; Miquel Quer; Gordana Halec; Beatriz Quiros; Sara Tous; Omar Clavero; Llucia Alos; Thorsten Biegner; Tomasz Szafarowski; Maria Alejo; Dana Holzinger; Enrique Cadena; Edith Claros; Gillian Hall; Jan Laco; Mario Poljak; Maria Benevolo; Elena Kasamatsu; Hisham Mehanna; Cathy Ndiaye; Nuria Guimera; Belen Lloveras; Xavier Leon; Juan C. Ruiz-Cabezas; Isabel Alvarado-Cabrero; Chang-Suk Kang; Jin-Kyoung Oh; Marcial Garcia-Rojo; Ermina Iljazovic; Oluseyi F. Ajayi; Flora Duarte; Ashrafun Nessa; Leopoldo Tinoco; Marco A. Duran-Padilla; Edyta C. Pirog; Halina Viarheichyk; Hesler Morales; Valerie Costes; Ana Felix; Maria Julieta V. Germar; Marisa Mena; Arzu Ruacan; Asha Jain; Ravi Mehrotra; Marc T. Goodman; Luis Estuardo Lombardi; Annabelle Ferrera; Sani Malami; Estela I. Albanesi; Pablo Dabed; Carla Molina; Ruben Lopez-Revilla; Vaclav Mandys; Manuel E. Gonzalez; Julio Velasco; Ignacio G. Bravo; Wim Quint; Michael Pawlita; Nubia Munoz; Silvia de Sanjose; F. Xavier Bosch.  

JNCI Journal of the National Cancer Institute 2016 108 (6): djv403 doi: 10.1093/jnci/djv403

Geographic variation in human papillomavirus oropharyngeal cancer: Data from 4 multi-national randomised trials.

Mehanna H, Franklin N, Compton N, Robinson M, Powell N, Biswas-Baldwin N, Paleri V, Hartley A, Fresco L, Al-Booz H, Junor E, El-Hariry I, Roberts S, Harrington K, Ang K, Dunn J,  Woodman C.

Head and Neck, in print 2015

Postoperative Adjuvant Lapatinib and Concurrent Chemoradiotherapy Followed by Maintenance Lapatinib Monotherapy in High-Risk Patients With Resected Squamous Cell Carcinoma of the Head and Neck: A Phase III, Randomized, Double-Blind, Placebo-Controlled Study

Harrington K, Temam S, Mehanna H, D'Cruz A, Jain M, D'Onofrio I, Manikhas G, Horvath Z, Sun Y, Dietzsch S, Dubinsky P, Holeckova P, El-Hariry I, Franklin N, Biswas-Baldwin N, Legenne P, Wissel P, Netherway T, Farrell J, Ellis C, Wang-Silvanto J, Amonkar M, Ahmed N, Santillana S, Bourhis J.

J Clin Oncol. 2015 Nov 2. pii: JCO.2015.61.4370. [Epub ahead of print]

Interventions in randomised controlled trials in surgery: issues to consider during trial design.

Blencowe NS, Brown JM, Cook JA, Metcalfe C, Morton DG, Nicholl J, Sharples LD, Treweek S, Blazeby JM; Members of the MRC Hub for Trials Methodology Research Network Workshop.

Trials. 2015 Sep 4;16:392. doi: 10.1186/s13063-015-0918-4.

The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.

Sahasrabudhe R1, Estrada A1, Lott P1, Martin L1, Polanco Echeverry G2, Velez A1, Neta G1, Takahasi M2, Saenko V1, Mitsutake N; JTCMS Consortium, Jaeguer E1, Duque CS1, Rios A1, Bohorquez M1, Prieto R1, Criollo A1, Echeverry M1, Tomlinson I1; CORGI Consortium; TCUKIN Consortiums, Carmona LG2.

Endocr Relat Cancer. 2015 Oct;22(5):841-9. doi: 10.1530/ERC-15-0081. Epub 2015 Aug 19.

External beam radiotherapy in differentiated thyroid carcinoma: A systematic review.              

Fussey JM, Crunkhorn R, Tedla M, Weickert MO, Mehanna H

Head Neck. 2015 Sep 3. doi: 10.1002/hed.24218. [Epub ahead of print]


IGF-1R expression is associated with HPV-negative status and adverse survival in head and neck squamous cell cancer.

Dale OT, Aleksic T, Shah KA, Han C, Mehanna H, Rapozo DC, Sheard JD, Goodyear P, Upile NS, Robinson M, Jones TM, Winter S, Macaulay VM.

Carcinogenesis. 2015 Jun;36(6):648-55. doi: 10.1093/carcin/bgv053. Epub 2015 Apr 20

Trends in head and neck cancers in England from 1995 to 2011 and projections up to 2025.

Louie KS, Mehanna H, Sasieni P

Oral Oncol. 2015 Jan 22. pii: S1368-8375(15)00003-2. doi: 10.1016/j.oraloncology.2015.01.002. [Epub ahead of print]

Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000.

Ness AR, Waylen A, Hurley K, Jeffreys M, Penfold C, Pring M, Leary S, Allmark C, Toms S, Ring S, Peters TJ, Hollingworth W, Worthington H, Nutting C, Fisher S, Rogers SN, Thomas SJ; Head and Neck 5000 Study Team

BMC Cancer. 2014 Dec 17;14:973. doi: 10.1186/1471-2407-14-973.


Resection of subsequent pulmonary metastases from treated head and neck squamous cell carcinoma; systematic review and meta-analysis.


Young ER, Diakos E, Khalid-Raja M, Mehanna H.

Clin Otolaryngol. 2014 Oct 30. doi: 10.1111/coa.12348. [Epub ahead of print]

PMID: 25358605 [PubMed - as supplied by publisher]

Differences in the Recurrence and Mortality Outcomes Rates of Incidental and Nonincidental Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-Analysis of 21 329 Person-Years of Follow-Up.

Mehanna H, Al-Maqbili T, Carter B, Martin E, Campain N, Watkinson J, McCabe C, Boelaert K, Franklyn JA.

J Clin Endocrinol Metab. 2014 May 14:jc20132118. [Epub ahead of print]

Investigation of p16(INK4a) as a prognostic biomarker in oral epithelial dysplasia.

Nankivell P, Williams H, Webster K, Pearson D, High A, MacLennan K, Senguven B, McConkey C, Rabbitts P, Mehanna H.

J Oral Pathol Med. 2014 Apr;43(4):245-9. doi: 10.1111/jop.12128. Epub 2013 Dec 26.

[PubMed - in process]

Revised radiobiological modelling of the contribution of synchronous chemotherapy to the rate of grades 3-4 mucositis in head and neck cancer.

Meade S, McConkey C, Sanghera P, Mehanna H, Hartley A.

J Med Imaging Radiat Oncol. 2013 Dec;57(6):733-8; quiz 739-40. doi: 10.1111/1754-9485.12096. Epub 2013 Jul 9.

Tetraspanins CD9 and CD151, epidermal growth factor receptor and cyclooxygenase-2 expression predict malignant progression in oral epithelial dysplasia.

Nankivell P, Williams H, McConkey C, Webster K, High A, MacLennan K, Senguven B, Rabbitts P, Mehanna H.

Br J Cancer. 2013 Nov 26;109(11):2864-74. doi: 10.1038/bjc.2013.600. Epub 2013 Nov 7.

LIHNCS - Lugol's iodine in head and neck cancer surgery: a multicentre, randomised controlled trial assessing the effectiveness of Lugol's iodine to assist excision of moderate dysplasia, severe dysplasia and carcinoma in situ at mucosal resection margins of oral and oropharyngeal squamous cell carcinoma: study protocol for a randomised controlled trial.

McCaul JA, Cymerman JA, Hislop S, McConkey C, McMahon J, Mehanna H, Shaw R, Sutton DN, Dunn J.

Trials. 2013 Sep 24;14:310. doi: 10.1186/1745-6215-14-310.

Simplified bone-anchored hearing aid insertion using a linear incision without soft tissue reduction.

Husseman J, Szudek J, Monksfield P, Power D, O’Leary S, Briggs R

J Laryngol Otology, 2013 Jul;127 Suppl 2:S33-8

Surgical trials in head & neck cancer - Are you serious?

Shaw R, Mehanna H.

Oral Oncol. 2013 Jun 28. doi:pii: S1368-8375(13)00609-X. 10.1016/j.oraloncology.2013.06.004. [Epub ahead of print]

Prolonged treatment with vitamin D in postmenopausal women with primary hyperparathyroidism.

Rao RR, Randeva HS, Sankaranarayanan S, Narashima M, Möhlig M, Mehanna H, Weickert MO.

Endocr Connect. 2012 Jun 8;1(1):13-21. doi: 10.1530/EC-12-0008. Print 2012 Jul 1.

Oncologic outcomes of transoral laser microsurgery for radiorecurrent laryngeal carcinoma: A systematic review and meta-analysis of English-language literature.

Ramakrishnan Y, Drinnan M, Kwong FN, Grant DG, Mehanna H, Jones T, Paleri V.

Head Neck. 2013 Jun 14. doi: 10.1002/hed.23291. [Epub ahead of print]

Barriers to recruitment for surgical trials in head and neck oncology: a survey of trial investigators.

Kaur G, Hutchison I, Mehanna H, Williamson P, Shaw R, Tudur Smith C.

BMJ Open. 2013 Apr 11;3(4). doi:pii: e002625. 10.1136/bmjopen-2013-002625. Print 2013.

Relations between cochlear histopathology and hearing loss in experimental cochlear implantation

SJ O'Leary, P Monksfield, G Kel, T Connolly, MA Souter, A Chang, P Marovic, JS O’Leary, R Richardson, H Eastwood

Hearing Research, 2013 Apr 298: 27-35

Randomised Phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: rationale for future randomised trials in human papilloma virus-negative disease.

Harrington K, Berrier A, Robinson M, Remenar E, Housset M, de Mendoza FH, Fayette J, Mehanna H, El-Hariry I, Compton N, Franklin N, Biswas-Baldwin N, Lau M, Legenne P, Kumar R.

Eur J Cancer. 2013 May;49(7):1609-18. doi: 10.1016/j.ejca.2012.11.023. Epub 2012 Dec 19.

The binary oral dysplasia grading system: validity testing and suggested improvement.

Nankivell P, Williams H, Matthews P, Suortamo S, Snead D, McConkey C, Mehanna H.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jan;115(1):87-94. doi: 10.1016/j.oooo.2012.10.015.

Malignancy risk analysis in patients with inadequate fine needle aspiration cytology (FNAC) of the thyroid.

Al Maqbali T, Tedla M, Weickert MO, Mehanna H.

PLoS One. 2012;7(11):e49078. doi: 10.1371/journal.pone.0049078. Epub 2012 Nov 19.

Salivary gland swellings.

Mehanna H, McQueen A, Robinson M, Paleri V.

BMJ. 2012 Oct 23;345:e6794. doi: 10.1136/bmj.e6794. Review. No abstract available.

Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis.

Rainsbury JW, Ahmed W, Williams HK, Roberts S, Paleri V, Mehanna H.

Head Neck. 2013 Jul;35(7):1048-55. doi: 10.1002/hed.22950. Epub 2012 Sep 20.

The new Nucleus 5 model cochlear implant: a new surgical technique and early clinical results.

Monksfield P, Husseman J, Cowan RSC, O’Leary SJ, Briggs RJS

Cochlear Implants International, 2012 Aug;13(3): 142-7

Validation of tissue microarrays in oral epithelial dysplasia using a novel virtual-array technique.

Nankivell PC, Williams H, Bartlett JM, Mehanna H.

J Clin Pathol. 2012 Dec;65(12):1084-7. doi: 10.1136/jclinpath-2012-200974. Epub 2012 Aug 22.

Feasibility of recruitment to an oral dysplasia trial in the United Kingdom.

Nankivell P, Dunn J, Langman M, Mehanna H.

Head Neck Oncol. 2012 Jun 25;4:40.

PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.

Smith VE, Read ML, Turnell AS, Sharma N, Lewy GD, Fong JC, Seed RI, Kwan P, Ryan G, Mehanna H, Chan SY, Darras VM, Boelaert K, Franklyn JA, McCabe CJ.

Endocrinology. 2012 Jul;153(7):3526-36. doi: 10.1210/en.2011-2030. Epub 2012 Apr 25.

Oropharyngeal cancer - is it time to change management according to human papilloma virus status?

Mehanna H, Olaleye O, Licitra L.

Curr Opin Otolaryngol Head Neck Surg. 2012 Apr;20(2):120-4. doi: 10.1097/MOO.0b013e3283509735.

Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24.

Jones AM, Howarth KM, Martin L, Gorman M, Mihai R, Moss L, Auton A, Lemon C, Mehanna H, Mohan H, Clarke SE, Wadsley J, Macias E, Coatesworth A, Beasley M, Roques T, Martin C, Ryan P, Gerrard G, Power D, Bremmer C; TCUKIN Consortium, Tomlinson I, Carvajal-Carmona LG.

J Med Genet. 2012 Mar;49(3):158-63. doi: 10.1136/jmedgenet-2011-100586. Epub 2012 Jan 25.

Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer--systematic review and meta-analysis of trends by time and region.

Mehanna H, Beech T, Nicholson T, El-Hariry I, McConkey C, Paleri V, Roberts S.

Head Neck. 2013 May;35(5):747-55. doi: 10.1002/hed.22015. Epub 2012 Jan 20.

Variation in volume definition between UK head and neck oncologists treating oropharyngeal carcinoma.

Pettit L, Hartley A, Bowden SJ, Mehanna H, Glaholm J, Cashmore J, Sanghera P.

Clin Oncol (R Coll Radiol). 2011 Nov;23(9):654-5. doi: 10.1016/j.clon.2011.07.006. Epub 2011 Aug 4. No abstract available.

Dexamethasone reduces pain, vomiting and overall complications following tonsillectomy in adults: a systematic review and meta-analysis of randomised controlled trials.

Diakos EA, Gallos ID, El-Shunnar S, Clarke M, Kazi R, Mehanna H.

Clin Otolaryngol. 2011 Dec;36(6):531-42. doi: 10.1111/j.1749-4486.2011.02373.x. Review.

Open conservation partial laryngectomy for laryngeal cancer: a systematic review of English langCost Effectiveness (Utility) Analysis of Bone Anchored Hearing Aids.

Monksfield P,  Jowett S, Reid AP and Proops DW

Otology Neurotology, 2011 Oct;32(8):1192-7

Biofilm formation on bone-anchored hearing aids

Monksfield P, Chapple ILC, Matthews JB, Grant MM, Addison O, Reid AP, Proops DW, Sammons RL

J Laryngol Otology, 2011 Nov;125(11):1125-30uage literature.


Open conservation partial laryngectomy for laryngeal cancer: a systematic review of English language literature.

Thomas L, Drinnan M, Natesh B, Mehanna H, Jones T, Paleri V.

Cancer Treat Rev. 2012 May;38(3):203-11. doi: 10.1016/j.ctrv.2011.05.010. Epub 2011 Jul 20. Review.

Biomarkers in laryngeal dysplasia: a systematic review.

Nankivell P, Weller M, McConkey C, Paleri V, Mehanna H.

Head Neck. 2011 Aug;33(8):1170-6. doi: 10.1002/hed.21592. Epub 2010 Nov 17. Review.

Re-feeding syndrome in head and neck--prevention and management.

Ahmed S, Travis J, Mehanna H.

Oral Oncol. 2011 Sep;47(9):792-6. doi: 10.1016/j.oraloncology.2010.06.009. Epub 2011 Jul 5. Review.

Head and neck cancer-part 1: epidemiology, presentation, and preservation.

Mehanna H, Paleri V, West CM, Nutting C.

Clin Otolaryngol. 2011 Feb;36(1):65-8. doi: 10.1111/j.1749-4486.2010.02231.x. Review. No abstract available.

Oncologic outcomes of open conservation laryngectomy for radiorecurrent laryngeal carcinoma: a systematic review and meta-analysis of English-language literature.

Paleri V, Thomas L, Basavaiah N, Drinnan M, Mehanna H, Jones T.

Cancer. 2011 Jun 15;117(12):2668-76. doi: 10.1002/cncr.25831. Epub 2011 Feb 1.

Review.Oral dysplasia: biomarkers, treatment, and follow-up.

Nankivell P, Mehanna H.

Curr Oncol Rep. 2011 Apr;13(2):145-52. doi: 10.1007/s11912-010-0150-z.

The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis.

Weller MD, Nankivell PC, McConkey C, Paleri V, Mehanna HM.

Clin Otolaryngol. 2010 Oct;35(5):364-72. doi: 10.1111/j.1749-4486.2010.02181.x. Review.

Who should be offered sperm banking for fertility preservation? A survey of UK oncologists and haematologists.

Gilbert E, Adams A, Mehanna H, Harrison B, Hartshorne GM.

Ann Oncol. 2011 May;22(5):1209-14. doi: 10.1093/annonc/mdq579. Epub 2010 Oct 27.

Head and neck cancer--Part 2: Treatment and prognostic factors.

Mehanna H, West CM, Nutting C, Paleri V.

BMJ. 2010 Sep 28;341:c4690. doi: 10.1136/bmj.c4690. Review. 

Hypofractionated accelerated radiotherapy with concurrent carboplatin for locally advanced squamous cell carcinoma of the head and neck.

Chan AK, Sanghera P, Choo BA, McConkey C, Mehanna H, Parmar S, Pracy P, Glaholm J, Hartley A.

Clin Oncol (R Coll Radiol). 2011 Feb;23(1):34-9. doi: 10.1016/j.clon.2010.07.015. Epub 2010 Sep 21.

Head and neck cancer--Part 1: Epidemiology, presentation, and prevention.

Mehanna H, Paleri V, West CM, Nutting C.

BMJ. 2010 Sep 20;341:c4684. doi: 10.1136/bmj.c4684. Review.

Correlation of currently used radiobiological parameters with local control and acute and late mucosal toxicity in randomised studies of altered fractionation for locally advanced head and neck cancer.

Hartley A, Sanghera P, Kazi W, Mehanna H, McConkey C, Glaholm J, Fowler J.

Clin Oncol (R Coll Radiol). 2011 Feb;23(1):29-33. doi: 10.1016/j.clon.2010.08.007. Epub 2010 Sep 9.


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