Featured publications
Mehanna H, Wong WL, McConkey C, Rahman JK, Robinson M, Hartley AG, Nutting C, Powell N, Al-Booz H, Robinson M, Junor E, Hulme C, Smith AF, Hall P, Dunn J. PETCT – guided surveillance versus planned neck dissection in advanced nodal disease of head and neck cancer treated by chemoradiotherapy.
N Engl J Med. 2016 Apr 14;374(15):1444-54. DOI: 10.1056/NEJMoa1514493. PMID: 27007578
Mehanna H, Robinson M, Hartley A, Kong A, Foran B, Fulton-Lieuw T, Dalby M, Mistry P, Sen M, O’Toole L, Booz H, Dyker K, Moleron R, Whitaker S, Brennan S, Cook A, Griffin M, Aynsley E, Rolles M, DeWinton E, Chan A, Srinivasan S, Grumett, J, Leemans C, Buter J, Henderson J, Harrington K, McConkey C, Gray A, Dunn J, on behalf of the De-ESCALaTE HPV Trial Group.
Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial.
Lancet. 2019 Jan 5;393(10166):51-60. doi: 10.1016/S0140-6736(18)32752-1. Epub 2018 Nov 15. PMID: 30449623
Mehanna H, Taberna M, von Buchwald C, Tous S, Brooks J, Mena M, Morey F, Grønhøj C, Rasmussen JH, Garset-Zamani M, Bruni L, Batis N, Brakenhoff RH, Leemans CR, Baatenburg de Jong RJ, Klussmann JP, Wuerdemann N, Wagner S, Dalianis T, Marklund L, Mirghani H, Schache A, James JA, Huang SH, O'Sullivan B, Nankivell P, Broglie MA, Hoffmann M, Quabius ES, Alemany L; HNCIG-EPIC group. Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis Lancet Oncol. 2023 Feb 13:S1470-2045(23)00013-X. doi: 10.1016/S1470-2045(23)00013-X. Online ahead of print. PMID: 36796393
Abou-Foul AK, Henson C, Chernock RD, Huang SH, Lydiatt WM, McDowell L, O'Sullivan B, Perez-Ordonez B, Robinson M, Nankivell PC, Ruiz-Bravo E, Chiosea SI, Green TM, Hunter KD, Hwang JS, Koljenovic S, Koppes SA, Larsen SR, Lo AWI, Costes-Martineau V, Mittal N, Mori T, Nagao T, Panayiotides IG, Pinto CAL, Scheckenbach K, Seethala RR, Ulhøi BP, Vingiani A, Zhang Y, Yom SS, Mehanna H
Standardised definitions and diagnostic criteria for extranodal extension detected on histopathological examination in head and neck cancer: Head and Neck Cancer International Group consensus recommendations.
Lancet Oncol. 2024 Jul;25(7):e286-e296. doi: 10.1016/S1470-2045(24)00143-8.PMID: 38936387
Henson, C., Abou-Foul, A., Glastonbury, C., Huang, S. H., King, A. D., Lydiatt, W. M., McDowell, L., Nagelschneider, A. A., Nankivell, P., O'Sullivan, B., Rhys, R., Xiao, Y., Yu, E., Andrew, D., Asmussen, J. T., Bidault, F., Dankbaar, J. W., de Graaf, P., Gebrim, E. S., Hu, C., & 13 others
Criteria for the diagnosis of extra nodal extension detected on radiological imaging in head and neck cancer: HNCIG international consensus recommendations
Lancet Oncol. 2024 Jul;25(7):e297-e307. doi: 10.1016/S1470-2045(24)00066-4.PMID: 38936388
Lim, A. M., McDowell, L., Hurt, C., Tourneau, C. L., Homma, A., Shenouda, G., Thompson, D. J., Moya-Plana, A., Henson, C., Szturz, P., Day, A. T., Bates, J. E., Lazarakis, S., Thariat, J., Psyrri, A., Mehanna, H. & Yom, S. S.,
Clinical trial endpoint use and definitions in curative-intent trials for mucosal head and neck squamous cell carcinomas: HNCIG international consensus recommendations.
Lancet Oncol. 2024 Jul;25(7):e318-e330. doi: 10.1016/S1470-2045(24)00067-6.PMID: 38936390 26 Jan 2024
Lim, A., Laskar, S., Steuer, C., Chow, V. L. Y., Szturz, P., Henson, C., Day, A. T., Bates, J. E., Lazarakis, S., McDowell, L., Mehanna, H. & Yom, S. S.,
Assessment of endpoint definitions in recurrent and metastatic mucosal head and neck squamous cell carcinoma trials: HNCIG international consensus recommendations.
Lancet Oncol. 2024 Jul;25(7):e308-e317. doi: 10.1016/S1470-2045(24)00068-8.PMID: 38936389
Mehanna H, Rapozo D, von Zeidler SV, Harrington KJ, Winter SC, Hartley A, Nankivell P, Schache AG, Sloan P, Odell EW, Thavaraj S, Hunter KD, Shah KA, Thomas GJ, Long A, Amel-Kashipaz R, Brown RM, Conn B, Hall GL, Matthews P, Weir J, Yeo Y, Pring M, West CML, McCaul J, Golusinski P, Sitch A, Spruce R, Batis N, Bryant JL, Brooks JM, Jones TM, Buffa F, Haider S, Robinson M.
Developing and Validating a Multivariable Prognostic-Predictive Classifier for Treatment Escalation of Oropharyngeal Squamous Cell Carcinoma: The PREDICTR-OPC Study.
Clin Cancer Res. 2024 Jan 17;30(2):356-367. doi: 10.1158/1078-0432.CCR-23-1013. PMID: 37870417; PMCID: PMC10792360.
Brooks JM, Menezes AN, Ibrahim M, Archer L, La Nl, Bagnall CJ, Zeidler SV, Valentine HR, Spruce RJ, Batis N, Bryant JL, Hartley M, Kaul N, Ryan GB, Bao R, Khattri A, Lee SL, Ogbureke KU, Middleton G, Tennant DA, Beggs AD, Deeks J, West CM, Cazier JB, Willcox BE, Seiwert TY and Mehanna H
Development and Validation of a Combined Hypoxia and Immune Prognostic Classifier for Head and Neck Cancer
Clin Cancer Res June 10 2019 DOI: 10.1158/1078-0432.CCR-18-3314 PMID: 31182433
Mehanna H, Hardman JC, Shenson JA, Abou-Foul AK, Topf MC, AlFalasi M, et al.
Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus.
Lancet Oncology. 2020 June 11; DOI:https://doi.org/10.1016/S1470-2045(20)30334-X. Epub 2020 Jun 11. PMID: 32534633; PMCID: PMC7289563.
